abstract：:We report new anticancer prodrugs, platinum(IV) derivatives of oxaliplatin conjugated with valproic acid (VPA), a well-known drug having histone deacetylase inhibitory activity. Like most platinum(IV) derivatives, the cytotoxicity of the conjugates was lower in cell culture than that of oxaliplatin, but greater than t...

journal_title：Journal of inorganic biochemistry

authors： Novohradsky V,Zerzankova L,Stepankova J,Vrana O,Raveendran R,Gibson D,Kasparkova J,Brabec V

更新日期：2014-11-01 00:00:00

abstract：:The coordination modes and geometry assumed in solution by the potent antitumor oxidovanadium(IV) complexes formed by different flavonoids were studied by spectroscopic (Electron Paramagnetic Resonance, EPR) and computational (Density Functional Theory, DFT) methods. A series of bidentate flavonoid ligands (L) with in...

journal_title：Journal of inorganic biochemistry

authors： Sanna D,Ugone V,Lubinu G,Micera G,Garribba E

更新日期：2014-11-01 00:00:00

abstract：:DNA condensation induced by a pair of heptameric La(III) helical enantiomers M-[La7(S-L)6(CO3)(NO3)6(OCH3)(CH3OH)7]·2CH3OH·5H2O and P-[La7(R-L)6(CO3)(NO3)6(OCH3)(CH3OH)5(H2O)2]·2CH3OH·4H2O (M-La and P-La, L=2-(2-hydroxybenzylamino)-3-carbamoylpropanoic acid) has been investigated by UV/vis spectroscopy, fluorescence s...

journal_title：Journal of inorganic biochemistry

authors： Bao FF,Xu XX,Zhou W,Pang CY,Li Z,Gu ZG

更新日期：2014-09-01 00:00:00

abstract：:A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for mo...

journal_title：Journal of inorganic biochemistry

authors： Hokai Y,Jurkowicz B,Fernández-Gallardo J,Zakirkhodjaev N,Sanaú M,Muth TR,Contel M

更新日期：2014-09-01 00:00:00

abstract：:Vanadium compounds exert various insulin-mimetic and anti-diabetic effects both in vitro and in vivo. Vanadium(III, IV, V)-chlorodipicolinate (Vdipic-Cl) compounds, including H[V(III)(dipic-Cl)2]·5H2O (V3dipic-Cl), V(IV)O(dipic-Cl)(H2O)2 (V4dipic-Cl) and K[V(V)O2(dipic-Cl)] (V5dipic-Cl), were synthesized with the indi...

journal_title：Journal of inorganic biochemistry

authors： Xie M,Chen D,Zhang F,Willsky GR,Crans DC,Ding W

更新日期：2014-07-01 00:00:00

abstract：:Cobalt(III) triarylcorroles containing 0-3 nitro groups on the para-position of the three meso-phenyl rings of the macrocycle were synthesized and characterized by electrochemistry, mass spectrometry, (UV-vis) and (1)H NMR spectroscopy. The examined compounds are represented as (NO2Ph)(n)Ph(3-n)CorCo(PPh3), where n va...

journal_title：Journal of inorganic biochemistry

authors： Li B,Ou Z,Meng D,Tang J,Fang Y,Liu R,Kadish KM

更新日期：2014-07-01 00:00:00

abstract：:Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)3](ClO4)2·2H2O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize th...

journal_title：Journal of inorganic biochemistry

authors： Zhang J,Yu Q,Li Q,Yang L,Chen L,Zhou Y,Liu J

更新日期：2014-05-01 00:00:00

abstract：:The anticancer drug cisplatin was encapsulated within the cucurbit[7]uril macrocycle to form the host-guest complex: cisplatin@CB[7]. This was then incorporated into gelatin and 0-4% w/v polyvinyl alcohol (PVA)-based hydrogels as slow release drug delivery vehicles. The hydrogels demonstrated predicable swelling and d...

journal_title：Journal of inorganic biochemistry

authors： Oun R,Plumb JA,Wheate NJ

更新日期：2014-05-01 00:00:00

abstract：:Iron is an essential nutrient for most bacteria. Depending on the oxygen available in the surrounding environment, iron is found in two distinct forms: ferrous (Fe(II)) or ferric (Fe(III)). Bacteria utilize different transport systems for the uptake of the two different forms of iron. In oxic growth conditions, iron i...

journal_title：Journal of inorganic biochemistry

authors： Carpenter C,Payne SM

更新日期：2014-04-01 00:00:00

abstract：:Copper based nanoparticles (Cu-based NPs) of different compositions and sizes have been hydrothermally synthesized by varying the reaction time in the presence of the biocompatible surfactants polyoxyethylene (20) sorbitan laurate (Tween 20) and polyethylene glycol 8000 (PEG 8000). Effective control of the above synth...

journal_title：Journal of inorganic biochemistry

authors： Giannousi K,Lafazanis K,Arvanitidis J,Pantazaki A,Dendrinou-Samara C

更新日期：2014-04-01 00:00:00

abstract：:The first reported homogenous rare earth curcumin (HCurc; ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione)) complexes with the formula ML3, where M(3+) is Eu(III), Gd(III) or Lu(III), were synthesized and characterized by mass spectrometry, infrared spectroscopy and, in the case of the lutetium co...

journal_title：Journal of inorganic biochemistry

authors： Mawani Y,Orvig C

更新日期：2014-03-01 00:00:00

abstract：:The dinuclear complex [Zn(2)(DPCPMP)(pivalate)](ClO4), where DPCPMP is the new unsymmetrical ligand [2-(N-(3-((bis((pyridin-2-yl)methyl)amino)methyl)-2-hydroxy-5-methylbenzyl)-N-((pyridin-2-yl)methyl)amino)acetic acid], has been synthesized and characterized. The complex is a functional model for zinc phosphoesterases...

journal_title：Journal of inorganic biochemistry

authors： Das B,Daver H,Pyrkosz-Bulska M,Persch E,Barman SK,Mukherjee R,Gumienna-Kontecka E,Jarenmark M,Himo F,Nordlander E

更新日期：2014-03-01 00:00:00

abstract：:The psychrophilic, hydrocarbonoclastic microorganism Colwellia psychrerythraea is important in global nutrient cycling and bioremediation. In order to investigate how this organism can live so efficiently at low temperatures (~4°C), thermal denaturation studies of a small electron transfer protein from Colwellia were ...

journal_title：Journal of inorganic biochemistry

authors： Oswald VF,Chen W,Harvilla PB,Magyar JS

更新日期：2014-02-01 00:00:00

abstract：:The zinc coordination sphere in prokaryotic zinc finger domain is extremely versatile and influences the stability and the folding property of the domain. Of a particular interest is the fourth zinc coordinating position, which is frequently occupied by two successive histidines, both able to coordinate the metal ion....

journal_title：Journal of inorganic biochemistry

authors： Palmieri M,Russo L,Malgieri G,Esposito S,Baglivo I,Rivellino A,Farina B,de Paola I,Zaccaro L,Milardi D,Isernia C,Pedone PV,Fattorusso R

更新日期：2014-02-01 00:00:00

abstract：:The efficiency of [Cu(2,2'-bipyridine)2(NO3)]NO3, [Cu(2,2'-dipyridylamine)2(NO3)2], and [Cu(dipicolylamine)2(NO3)2] complexes (complex 1, 2 and 3, respectively) in oxidative DNA cleavage was examined by electrophoresis and linear dichroism (LD). Among the three Cu complexes, complex 1 showed the highest efficiency in ...

journal_title：Journal of inorganic biochemistry

authors： Kwon JH,Park HJ,Chitrapriya N,Cho TS,Kim S,Kim J,Hwang IH,Kim C,Kim SK

更新日期：2014-02-01 00:00:00

abstract：:The study of interactions between proteins and nanoparticles is important to advancing applications of nanoparticles in biology, medicine, and materials science. Here, we report the encapsulation of a 5-nm diameter gold nanoparticle (AuNP) by thermophilic ferritin (tF), achieved in nearly quantitative yield under mild...

journal_title：Journal of inorganic biochemistry

authors： Cheung-Lau JC,Liu D,Pulsipher KW,Liu W,Dmochowski IJ

更新日期：2014-01-01 00:00:00

abstract：:The bifunctional Pt(IV) conjugate cis,cis,trans-diamminedichloridobis(valproato)platinum(IV), based on the cisplatin square-plane with two axial valproato (2-propylpentanoate, VPA) ligands, has been re-synthesized with a modified procedure and its biological activity was compared with that of its isomer cis,cis,trans-...

journal_title：Journal of inorganic biochemistry

authors： Alessio M,Zanellato I,Bonarrigo I,Gabano E,Ravera M,Osella D

更新日期：2013-12-01 00:00:00

abstract：:Ruthenium complexes hold a great potential in chemotherapy as an alternative to the classical platinum based drugs. The organometallic compounds studied in the present work were previously found to exhibit important anticancer activities. Here we have investigated the binding of three ruthenium compounds, namely [Ru(η...

journal_title：Journal of inorganic biochemistry

authors： Morais TS,Santos FC,Corte-Real L,Garcia MH

更新日期：2013-12-01 00:00:00

abstract：:A systematic density functional theory study supported by extended X-ray absorption fine structure (EXAFS) and infrared spectroscopic data was conducted to elucidate how structure and vibrational spectra of aqueous desferrioxamine B (DFOB) metal complexes vary with the metal ion identity. Structural parameters derived...

journal_title：Journal of inorganic biochemistry

authors： Kruft BI,Harrington JM,Duckworth OW,Jarzęcki AA

更新日期：2013-12-01 00:00:00

abstract：:Dysregulation of apoptosis and necrosis is central to many diseases and non-invasive imaging of cell death is an important clinical objective to stage disease or to monitor treatment progress. The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysin...

journal_title：Journal of inorganic biochemistry

authors： Hueting R,Tavaré R,Dilworth JR,Mullen GE

更新日期：2013-11-01 00:00:00

abstract：:The use of chelating agents for iron and aluminum in different clinical applications has found increasing attention in the last thirty years. Desferal, deferiprone and deferasirox, chelating agents nowadays in use, are based on hydroxamic groups, hydroxyl-substituted pyridinones or aromatic ring systems. With the aim ...

journal_title：Journal of inorganic biochemistry

authors： Toso L,Crisponi G,Nurchi VM,Crespo-Alonso M,Lachowicz JI,Santos MA,Marques SM,Niclós-Gutiérrez J,González-Pérez JM,Domínguez-Martín A,Choquesillo-Lazarte D,Szewczuk Z

更新日期：2013-10-01 00:00:00

abstract：:The antitumoral potential for a series of platinum iodido complexes, all bearing the same aliphatic amines (first iodido complexes generation), was demonstrated in a previous study. Concretely, cis complexes were shown to have a peculiar and different reactivity compared to cisplatin with sulfur donors models and Cyt ...

journal_title：Journal of inorganic biochemistry

authors： Parro T,Medrano MA,Cubo L,Muñoz-Galván S,Carnero A,Navarro-Ranninger C,Quiroga AG

更新日期：2013-10-01 00:00:00

abstract：:A series of hybrid quantum mechanical/molecular mechanical (QM/MM) calculations was performed on models of a DNA duplex with artificial silver(I)-mediated imidazole base pairs. The optimized structures were compared to the original experimental NMR structure (Nat. Chem. 2 (2010) 229-234). The metal⋯metal distances are...

journal_title：Journal of inorganic biochemistry

authors： Kumbhar S,Johannsen S,Sigel RK,Waller MP,Müller J

更新日期：2013-10-01 00:00:00

abstract：:HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1α. Prior s...

journal_title：Journal of inorganic biochemistry

authors： Pektas S,Knapp MJ

更新日期：2013-09-01 00:00:00

abstract：:The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV-vis and EPR spectra. S/N-linkage isomerism was explored on Co(III) and Co(II) Cbl and Cbi models using density functional theory (DFT; BP86, B3LYP). Performed calculations suggest the prevalence of isothioc...

journal_title：Journal of inorganic biochemistry

authors： Dereven'kov IA,Salnikov DS,Makarov SV,Surducan M,Silaghi-Dumitrescu R,Boss GR

更新日期：2013-08-01 00:00:00

abstract：:Tiopronin, a synthetic thiol-containing drug being used in treatments of cystinuria and certain types of rare arthritis, is also a hepatoprotective and a detoxifying agent. Many analytical methods have been developed based on its redox chemistry with metal ions/complexes, but the kinetic and mechanistic aspects are po...

journal_title：Journal of inorganic biochemistry

authors： Huo S,Shi H,Liu D,Shen S,Zhang J,Song C,Shi T

更新日期：2013-08-01 00:00:00

abstract：:The antineoplastic potential of a new stable mixed phosphine gold(I) complex containing tris(tert-butyl)phosphine (tBu3P) and bis(diphenylphosphino)ethene (dppet), namely [Au(tBu3P)(dppet)Cl], has been investigated in the human colon cancer HCT-116 cell line. The (31)P NMR solution study, confirms the structural featu...

journal_title：Journal of inorganic biochemistry

authors： Lupidi G,Avenali L,Bramucci M,Quassinti L,Pettinari R,Khalife HK,Gali-Muhtasib H,Marchetti F,Pettinari C

更新日期：2013-07-01 00:00:00

abstract：:The synthesis of the Co(III) porphyrin octapeptide N-acetyl-Co(III) microperoxidase-8 (NAcCoMP8) is described. NAcCoMP8 provides a means of comparing and contrasting the chemistry of Co(III) porphyrins and corrins to assess the influence of the macrocycle. Log K values, and ΔH and ΔS, for the coordination of anionic (...

journal_title：Journal of inorganic biochemistry

authors： Mathura S,Sannasy D,de Sousa AS,Perry CB,Navizet I,Marques HM

更新日期：2013-06-01 00:00:00

abstract：:Anticancer activity of the new [Ru(η(5)-C5H5)(PPh3)(Me2bpy)][CF3SO3] (Me2bpy = 4,4'-dimethyl-2,2'-bipyridine) complex was evaluated in vitro against several human cancer cell lines, namely A2780, A2780CisR, HT29, MCF7, MDAMB231 and PC3. Remarkably, the IC50 values, placed in the nanomolar and sub-micromolar range, lar...

journal_title：Journal of inorganic biochemistry

authors： Morais TS,Santos F,Côrte-Real L,Marques F,Robalo MP,Madeira PJ,Garcia MH

更新日期：2013-05-01 00:00:00

abstract：:The mechanism of action of clinically used Pt-based drugs is through the formation of stable DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two spatially closed residues. Nevertheless, proteins can represent alternative targets since in particular sulfur groups, present in cys...

journal_title：Journal of inorganic biochemistry

authors： Pinato O,Musetti C,Farrell NP,Sissi C

更新日期：2013-05-01 00:00:00

abstract：:The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the binding of V(IV)O(2+) to hTF, as well as whether the conformation of hTF upon binding to V(IV)O(2+) or to its complexes is ch...

journal_title：Journal of inorganic biochemistry

authors： Mehtab S,Gonçalves G,Roy S,Tomaz AI,Santos-Silva T,Santos MF,Romão MJ,Jakusch T,Kiss T,Pessoa JC

更新日期：2013-04-01 00:00:00

abstract：:To explore the correlating thermodynamic factors to the structural aspects that account for the stability of the RNA triplex, two functional Ru(II) complexes containing the same ancillary ligands and different intercalative ligands, [Ru(bpy)(2)(mip)](2+) (bpy=2,2'-bipyridine, mip=2'-(3",4"-methylene-dioxyphenyl)imidaz...

journal_title：Journal of inorganic biochemistry

authors： Tan L,Xie L,Sun X,Zeng L,Yang G

更新日期：2013-03-01 00:00:00

abstract：:Catalytic mechanisms of reduction of O(2) to 2H(2)O by respiratory terminal oxidases have been extensively investigated. Tri-heme (b(558), b(595), d) cytochrome bd oxidases presumably utilize a dihemic site composed of high-spin hemes d and b(595). We performed a CO photolysis/recombination study of the purified fully...

journal_title：Journal of inorganic biochemistry

authors： Borisov VB,Verkhovsky MI

更新日期：2013-01-01 00:00:00

abstract：:Nitroxyl (HNO) has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during decomposition limits the use of AS requiring other HNO sources. Acyloxy nitroso c...

journal_title：Journal of inorganic biochemistry

authors： DuMond JF,Wright MW,King SB

更新日期：2013-01-01 00:00:00

abstract：:The reactivity of coordinated nitroxyl (HNO) has been explored with the [Fe(II)(CN)(5)HNO](3-) complex in aqueous medium, pH 6. We discuss essential biorelevant issues as the thermal and photochemical decompositions, the reactivity toward HNO dissociation, the electrochemical behavior, and the reactions with oxidizing...

journal_title：Journal of inorganic biochemistry

authors： Montenegro AC,Bari SE,Olabe JA

更新日期：2013-01-01 00:00:00

abstract：:The reactions of several horse heart myoglobin species with nitrosyl hydride, HNO, derived from Angeli's salt (AS) and Piloty's acid (PA) have been followed by UV-visible, (1)H NMR and EPR spectroscopies. Spectral analysis of myoglobin-derived speciation during the reactions was obtained by using singular value decomp...

journal_title：Journal of inorganic biochemistry

authors： Zapata AL,Kumar MR,Pervitsky D,Farmer PJ

更新日期：2013-01-01 00:00:00

abstract：:A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives, with electron-withdrawing and -donating substituents include methyl, nitro, fluoro, tri-isopropyl, trifl...

journal_title：Journal of inorganic biochemistry

authors： Sirsalmath K,Suárez SA,Bikiel DE,Doctorovich F

更新日期：2013-01-01 00:00:00

abstract：:A novel antimony-phthalocyanine, [Sb(H(3)tsppc)(OH)(2)], where H(3)tsppc denotes monodeprotonated tetrakis{(2',6'-dimethyl-4'-sulfonic acid)phenoxyl}phthalocyaninate, has been synthesized through sulfonation of [Sb(tppc)(OH)(2)](+) (tppc denotes tetrakis{(2',6'-dimethyl)phenoxyl}phthalocyaninate) in concentrated sulfu...

journal_title：Journal of inorganic biochemistry

authors： Isago H,Fujita H,Sugimori T

更新日期：2012-12-01 00:00:00

abstract：:The stoichiometry and stability constants of the Ga(III) complexes of 8-hydroxyquinoline (HQ), 8-hydroxyquinoline-5-sulfonate (HQS), maltol, thiomaltol, allomaltol and thioallomaltol were determined by means of pH-potentiometry, UV-vis spectrophotometry, spectrofluorometry and (1)H NMR spectroscopy in aqueous solution...

journal_title：Journal of inorganic biochemistry

authors： Enyedy ÉA,Dömötör O,Varga E,Kiss T,Trondl R,Hartinger CG,Keppler BK

更新日期：2012-12-01 00:00:00

abstract：:In order to develop in vitro methods as an alternative to P450 animal testing in the drug discovery process, two main requisites are necessary: 1) gathering of data on animal homologues of the human P450 enzymes, currently very limited, and 2) bypassing the requirement for both the P450 reductase and the expensive cof...

journal_title：Journal of inorganic biochemistry

authors： Rua F,Sadeghi SJ,Castrignanò S,Di Nardo G,Gilardi G

更新日期：2012-12-01 00:00:00